Stylianos E. Antonarakis is currently Professor and Chairman of Genetic Medicine atthe University of Geneva Medical School, President of HUGO, and the founding director of iGE3 (institute of Genetics and Genomics of Geneva). He is a medical, molecular, human geneticist, physician-scientist. He received his MD (1975) and DSc (1982) from the University of Athens Medical School. He joined the faculty of the Johns Hopkins University in 1983 and rose to full professor of Pediatric Genetics, Biology and Medicine in 1990. He has published more than 660 papers and he is listed as one of the highly cited scientists by the ISI institute with more than 51,000 citations. He has received numerous awards including thecommander of the Order of Phoenix medal from the Hellenic Democracy (2007). Some of his current interests and research projects are the functional analysis of the genome, effect of human genetic variation to phenotypic variation, and the molecular pathogenesis of trisomy 21 andpolygenic phenotypes.